In the Blue Square Bet North, Guiseley aim to consolidate their top-five position, while Woking look to extend their lead at the top of the South standings.
Worcester City have an opportunity to extend their three-game winning streak and push for a spot in the play-offs when they host Gainsborough Trinity, who occupy the final play-off position.
Relegation candidates Hinckley United host 10th-placed Boston United on Monday night.
The Knitters are only two points clear of the danger zone but are in top form after winning their last two league games convincingly, while the Pilgrims beat Stalybridge in their last outing.
Droylsden come into their Tuesday clash against Blyth Spartans on the back of a 3-2 defeat to Histon.
The Bloods are 16th in the standings after the defeat, while the Spartans are 21st - 11 points from safety and desperate for win.
Third-placed FC Halifax are at home for their tie with Bishop's Stortford. The Shaymen are on 57 points, two clear of fifth-placed Trinity, while Bishops are 15th and just five points above the drop zone.
Fourth-placed Guiseley will look to consolidate their place in the top five when they welcome 13th-placed Solihull Moors to Nethermoor Park.
Meanwhile, in the Blue Square Bet South, league leaders Woking can strengthen their position when they host eighth-placed Dorchester Town at Kingfield Stadium.
The Cardinals are six points clear of second-placed Dartford, who are away at 16th-placed Maidenhead on Tuesday.
Hampton & Richmond Borough face Dover Athletic at Beveree Stadium after a valuable 4-3 win over Truro on Saturday.
The Beavers are in 21st position and five points from safety, while the sixth-placed Whites are hunting down the top five.
Staines Town can lift themselves out of the relegation zone with a win over visitors Tonbridge Angels.
The Swans are in 20th position but only one point behind Eastbourne Borough, while the Angels are in 10th place.
Truro City are desperate to stop the rot as they host Boreham Wood at Treyew Road.
The 15th-placed White Tigers have lost their last four ties, while 13th-placed Wood come into the game on the back of a 2-2 draw with Dorchester.
In the only fixture on Wednesday, Sutton United will host 19th-placed Eastbourne Borough.
The Us are in fourth position and three points clear of fifth-placed Chelmsford. The Sports, meanwhile, are a point above the drop zone.
Hinckley Utd v Boston Utd
Worcester v Gainsborough
Droylsden v Blyth Spartans
FC Halifax v Bishop's Stortford
Guiseley v Solihull Moors
Hampton & Richmond v Dover
Maidenhead Utd v Dartford
Staines Town v Tonbridge Angels
Truro City v Boreham Wood
Woking v Dorchester
Sutton Utd v Eastbourne Borough
All games kick off at 19:45
Players leaving so it will be a new start in many ways I think...hope new manager is announced soon o... MORE >>
By orpewise on Mon, 20th May 13
|BlueSq South Standings|
|10||Havant and Waterlooville||58|